Solving Critical Unmet Needs In The Fields Of Endocrine Dysregulation And Immuno-oncology
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Carcinogenesis, Volume 41, Issue 9, September 2020
MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment
Chronic inflammation is a highly prevalent consequence of changes in environmental and lifestyle factors that contribute to the development of cancer. The basis for this critical association has largely remained unclear
JCI Insight June 2020
MUC1-C drives stemness in progression of colitis to colorectal cancer
Colitis is associated with the development of colorectal cancer (CRC) by largely undefined mechanisms that are critical for understanding the link between inflammation and cancer. Intestinal stem cells (ISCs) marked by leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) expression are of importance in both the inflammatory response to colitis and progression to colitis-associated colon cancer (CACC)
JCI Insight June 2018
Targeting the human MUC1-C oncoprotein with an antibodydrug conjugate
Mucin 1 (MUC1) is a heterodimeric protein that is aberrantly overexpressed on the surface of diverse human carcinomas and is an attractive target for the development of mAb-based therapeutics. However, attempts at targeting the shed MUC1 N-terminal subunit have been unsuccessful.