Publications

Scientific Papers in Oncology

Kufe DW. MUC1-C in chronic inflammation and carcinogenesis; emergence as a target for cancer treatment. Carcinogenesis. 2020 Sep 24;41(9):1173-1183. doi: 10.1093/carcin/bgaa082. PMID: 32710608; PMCID: PMC7513951.

Li W, Zhang N, Jin C, Long MD, Rajabi H, Yasumizu Y, Fushimi A, Yamashita N, Hagiwara M, Zheng R, Wang J, Kui L, Singh H, Kharbanda S, Hu Q, Liu S, Kufe D. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight. 2020 Jun 18;5(12):e137112. doi: 10.1172/jci.insight.137112. PMID: 32427590; PMCID: PMC7406273.

Panchamoorthy G, Jin C, Raina D, Bharti A, Yamamoto M, Adeebge D, Zhao Q, Bronson R, Jiang S, Li L, Suzuki Y. Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate. JCI insight. 2018 Jun 6;3(12).

Maeda T, Hiraki M, Jin C, Rajabi H, Tagde A, Alam M, Bouillez A, Hu X, Suzuki Y, Miyo M, Hata T, Hinohara K, Kufe D. MUC1-C Induces PD-L1 and Immune Evasion in Triple-Negative Breast Cancer. Cancer Res. 2018 Jan 1;78(1):205-215. doi: 10.1158/0008-5472.CAN-17-1636. Epub 2017 Dec 20. PMID: 29263152; PMCID: PMC5754244.

Bouillez A, Adeegbe D, Jin C, Hu X, Tagde A, Alam M, Rajabi H, Wong KK, Kufe D. MUC1-C promotes the suppressive immune microenvironment in non-small cell lung cancer. Oncoimmunology. 2017 Jul 5;6(9):e1338998. doi: 10.1080/2162402X.2017.1338998. PMID: 28932637; PMCID: PMC5599083.

Pyzer AR, Stroopinsky D, Rosenblatt J, Anastasiadou E, Rajabi H, Washington A, Tagde A, Chu JH, Coll M, Jiao AL, Tsai LT, Tenen DE, Cole L, Palmer K, Ephraim A, Leaf RK, Nahas M, Apel A, Bar-Natan M, Jain S, McMasters M, Mendez L, Arnason J, Raby BA, Slack F, Kufe D, Avigan D. MUC1 inhibition leads to decrease in PD-L1 levels via upregulation of miRNAs. Leukemia. 2017 Dec;31(12):2780-2790. doi: 10.1038/leu.2017.163. Epub 2017 May 30. PMID: 28555079; PMCID: PMC5791150.

Rajabi H, Kufe D. MUC1-C Oncoprotein Integrates a Program of EMT, Epigenetic Reprogramming and Immune Evasion in Human Carcinomas. Biochim Biophys Acta Rev Cancer. 2017 Aug;1868(1):117-122. doi: 10.1016/j.bbcan.2017.03.003. Epub 2017 Mar 14. PMID: 28302417; PMCID: PMC5548633.

MUC1-mediated induction of myeloid-derived suppressor cells in patients with acute myeloid leukemia
Blood ; 129(13):1791-1801; Pyzer AR, Stroopinsky D, Rajabi H, Washington A, Tagde A, Coll M, Fung J, Bryant MP, Cole L, Palmer K, Somaiya P, Leaf RK, Nahas M, Apel A, Jain S, McMasters M, Mendez L, Levine J, Joyce R, Arnason J, Pandolfi PP, Kufe D, Rosenblatt J, and Avigan D.

MUC1-C integrates PD-L1 induction with repression of immune effectors in non-small cell lung cancer
Oncogene , Jan 2017; 36:4037-4046; Bouillez A, Rajabi H, Jin C, Samur M, Tagde A, Alam M, Hiraki M, Maeda T, Hu X, Adeegbe D, Kharbanda S, Wong K-K and Kufe D. 

Intracellular targeting of the oncogenic MUC1-C protein with a novel GO-203 nanoparticle formulation
Clinical Cancer Research , 2015; 21(10):2338-2347; Hasegawa M, Sinha RK, Kumar M, Alam M, Yin L, Raina D, Kharbanda A, Panchamoorthy G, Gupta D, Singh H, Kharbanda S, and Kufe D.

Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma
Mol Cancer Ther ; 16(10):2304-2314; Jain S, Washington A, Leaf RK, Bhargava P, Clark RA, Kupper TS, Stroopinsky D, Pyzer A, Cole L, Nahas M, Apel A, Rosenblatt J, Arnason J, Kufe D, and Avigan D. 

Bone marrow stroma protects myeloma cells from cytotoxic damage via induction of the oncoprotein MUC1
Br J Haematol , 2017; 176(6):929-936; Bar-Natan M, Stroopinsky D, Luptakova K, Coll MD, Apel A, Rajabi H, Pyzer AR, Palmer K, Reagan MR, Nahas MR, Karp Leaf R, Jain S, Arnason J, Ghobrial IM, Anderson KC, Kufe D, Rosenblatt J, and Avigan D. 

Scientific Papers in Endocrinology

Huang G, Bhasin S, Pencina K, Cheng M, Jasuja R. Circulating dihydrotestosterone, testosterone, and free testosterone levels and dihydrotestosterone-to-testosterone ratios in healthy women across the menstrual cycle. Fertil Steril. 2022 Nov 09. PMID: 36371319.

Jasuja R, Pencina KM, Spencer DJ, Peng L, Privat F, Dhillo W, Jayasena C, Hayes F, Yeap BB, Matsumoto AM, Bhasin S. Reference intervals for free testosterone in adult men measured using a standardized equilibrium dialysis procedure. Andrology. 2022 Oct 17. PMID: 36251328.

Jasuja R, Pencina KM, Peng L, Bhasin S. Accurate Measurement and Harmonized Reference Ranges for Total and Free Testosterone Levels. Endocrinol Metab Clin North Am. 2022 03; 51(1):63-75. PMID: 35216721.

Jasuja R, Spencer D, Jayaraj A, Peng L, Krishna M, Lawney B, Patel P, Jayaram B, Thayer KM, Beveridge DL, Bhasin S. Estradiol induces allosteric coupling and partitioning of sex-hormone-binding globulin monomers among conformational states. iScience. 2021 Jun 25; 24(6):102414. PMID: 34041454; PMCID: PMC8144348.

Zakharov MN, Bhasin S, Travison TG, Xue R, Ulloor J, Ramachandran V, Carter E, Wu F, Jasuja R. Corrigendum to “A multi-step, allosteric model of testosterone’s binding to sex hormone binding globulin” [Mol. Cell. Endocrinol. 399 (2015) 190-200]. Mol Cell Endocrinol. 2017 10 15; 454:167. PMID: 28780939.